β-catenin promotes T regulatory cell responses in tumors by inducing vitamin A metabolism in dendritic cells Running Title: β-catenin/Retinoic Acid -Mediated Tumor Immune Tolerance
نویسندگان
چکیده
Cancer Immunology, Inflammation, and Tolerance Program, GRU Cancer Center, Georgia Regents University, Augusta, Georgia, USA. Hunstman Cancer Institute, University of Utah, Salt Lake City, UT, USA. Department of Medicine, Medical College of Georgia, Georgia Regents University, Augusta, Georgia, USA. Department of Microbiology, University of Chicago, Chicago,IL, USA. Department of Pediatrics, Medical College of Georgia, Georgia Regents University, Augusta, Georgia, USA. *Authors contributed equally
منابع مشابه
β-catenin promotes regulatory T-cell responses in tumors by inducing vitamin A metabolism in dendritic cells.
Tumors actively suppress antitumor immunity, creating formidable barriers to successful cancer immunotherapy. The molecular mechanisms underlying tumor-induced immune tolerance are largely unknown. In the present study, we show that dendritic cells (DC) in the tumor microenvironment acquire the ability to metabolize vitamin A to produce retinoic acid (RA), which drives regulatory T-cell respons...
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Tumors actively suppress antitumor immunity, creating formidable barriers to successful cancer immunotherapy. The molecular mechanisms underlying tumor-induced immune tolerance are largely unknown. In the present study, we show that dendritic cells (DC) in the tumor microenvironment acquire the ability to metabolize vitamin A to produce retinoic acid (RA), which drives regulatory T-cell respons...
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